Brompheniramine, dihydrocodeine, and pseudoephedrine

Generic Name: brompheniramine, dihydrocodeine, and pseudoephedrine (BROM fen IR a meen, dye HYE droe KOE deen, SOO doe ee FED rin)

Brand Names: J-Cof DHC

What is brompheniramine, dihydrocodeine, and pseudoephedrine?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dihydrocodeine is in a group of drugs called narcotics and is similar to codeine. Dihydrocodeine is a cough suppressant that affects signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of brompheniramine, dihydrocodeine, and pseudoephedrine is used to treat cough, sneezing, itching, watery eyes, runny nose, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu.

Brompheniramine, dihydrocodeine, and pseudoephedrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about brompheniramine, dihydrocodeine, and pseudoephedrine?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Dihydrocodeine may be habit-forming and should be used only by the person it was prescribed for. Dihydrocodeine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Dihydrocodeine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription. Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant. This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What should I discuss with my healthcare provider before taking brompheniramine, dihydrocodeine, and pseudoephedrine?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Before taking brompheniramine, dihydrocodeine, and pseudoephedrine, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  kidney or liver disease;

  
  


• 
  

  heart disease or high blood pressure;

  
  


• 
  

  enlarged prostate or urination problems;

  
  


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  asthma, COPD, sleep apnea, or other breathing disorders;

  
  


• 
  

  a history of head injury or brain tumor;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  low blood pressure;

  
  


• 
  

  gallbladder disease;

  
  


• 
  

  Addison's disease or other adrenal gland disorders;

  
  


• 
  

  mental illness; or

  
  


• 
  

  a history of drug or alcohol addiction.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medication may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Dihydrocodeine may be habit-forming and should be used only by the person it was prescribed for. Dihydrocodeine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Dihydrocodeine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

How should I take brompheniramine, dihydrocodeine, and pseudoephedrine?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Cough or cold medicine is usually taken for only a short time until your symptoms clear up.

Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Store this medicine at room temperature, away from heat, light, and moisture.

See also: Brompheniramine, dihydrocodeine, and pseudoephedrine dosage (in more detail)

What happens if I miss a dose?

Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of dihydrocodeine can be fatal. Overdose symptoms may include extreme dizziness or drowsiness, confusion, feeling restless or nervous, cold and clammy skin, warmth or tingly feeling, nausea, vomiting, slow or shallow breathing, slow heart rate, pinpoint pupils, fainting, and seizure (convulsions).

What should I avoid while taking brompheniramine, dihydrocodeine, and pseudoephedrine?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather.

Do not drink alcohol while you are taking this medication. Alcohol can increase some of the side effects of brompheniramine, dihydrocodeine, and pseudoephedrine.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. Brompheniramine and pseudoephedrine are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant.

Brompheniramine, dihydrocodeine, and pseudoephedrine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

• 
  

  fast, pounding, or uneven heartbeats;

  
  


• 
  

  shallow breathing, slow heartbeat;

  
  


• 
  

  severe dizziness, fainting, anxiety, restless feeling, nervousness, or tremor;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

  
  


• 
  

  urinating less than usual or not at all; or

  
  


• 
  

  increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

  
  

Less serious side effects may include:

• 
  

  blurred vision;

  
  


• 
  

  dry mouth;

  
  


• 
  

  nausea, vomiting, stomach pain, constipation, mild loss of appetite;

  
  


• 
  

  mild dizziness, drowsiness;

  
  


• 
  

  problems with memory or concentration;

  
  


• 
  

  ringing in your ears;

  
  


• 
  

  warmth, tingling, or redness under your skin;

  
  


• 
  

  restless or excitability (especially in children);

  
  


• 
  

  sleep problems (insomnia); or

  
  


• 
  

  skin rash or itching.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Brompheniramine, dihydrocodeine, and pseudoephedrine Dosing Information

Usual Adult Dose for Cough and Nasal Congestion:

Brompheniramine/dihydrocodeine/PSE 3 mg-7.5 mg-15 mg/5 mL oral liquid:
5 to 10 mL orally every 4 to 6 hours.

Usual Pediatric Dose for Cough and Nasal Congestion:

Brompheniramine/dihydrocodeine/PSE 3 mg-7.5 mg-15 mg/5 mL oral liquid:
6 to 11 years: 2.5 mL to 5 mL orally every 4 to 6 hours.
12 years or older: 5 to 10 mL orally every 4 to 6 hours.

What other drugs will affect brompheniramine, dihydrocodeine, and pseudoephedrine?

Before taking this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by brompheniramine or dihydrocodine.

Before taking this medication, tell your doctor if you are using any of the following drugs:

• 
  

  an antidepressant such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others; or

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others;

  
  

This list is not complete and there may be other drugs that can interact with brompheniramine, dihydrocodeine, and pseudoephedrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More brompheniramine, dihydrocodeine, and pseudoephedrine resources

• Brompheniramine, dihydrocodeine, and pseudoephedrine Dosage
• Brompheniramine, dihydrocodeine, and pseudoephedrine Use in Pregnancy & Breastfeeding
• Brompheniramine, dihydrocodeine, and pseudoephedrine Drug Interactions
• Brompheniramine, dihydrocodeine, and pseudoephedrine Support Group
• 0 Reviews for Brompheniramine, dihydrocodeine, and pseudoephedrine - Add your own review/rating

Compare brompheniramine, dihydrocodeine, and pseudoephedrine with other medications

• Cold Symptoms
• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about brompheniramine, dihydrocodeine, and pseudoephedrine.

Boniva Intravenous

Generic Name: ibandronate (Intravenous route)

eye-BAN-droe-nate

Commonly used brand name(s)

In the U.S.

• Boniva

In Canada

• Bondronat

Available Dosage Forms:

• Solution

Therapeutic Class: Calcium Regulator

Chemical Class: Bisphosphonate

Uses For Boniva

Ibandronate injection is used to treat osteoporosis (thinning of the bone) in women after menopause.

This medicine is available only with your doctor's prescription.

Before Using Boniva

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ibandronate injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ibandronate injection in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Dairy Food


• food

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia or


• Blood clotting problems or


• Cancer or


• Dental or tooth problems or


• Dental procedures (e.g., tooth extraction) or


• Infection or


• Poor oral hygiene or


• Surgery (e.g., dental surgery)—May increase risk for severe jaw problems.

• Diabetes or


• Heart disease or


• Hypertension (high blood pressure)—Use with caution. May increase risk for more kidney problems.

• Hypocalcemia (low calcium in the blood), uncorrected or


• Hypovitaminosis D (low blood vitamin D) or


• Kidney disease, severe—Should not be used in patients with these conditions.

• Osteoporosis, family history of or


• Other bone problems or


• Previous broken bone—May increase risk for osteoporosis.

Proper Use of ibandronate

This section provides information on the proper use of a number of products that contain ibandronate. It may not be specific to Boniva. Please read with care.

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.

This medicine is usually given once every 3 months. If you missed a dose, call your doctor to make another appointment as soon as possible.

Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

This medicine comes with a patient information leaflet. Read and follow the instructions in the leaflet carefully. Ask your doctor if you have any questions.

Precautions While Using Boniva

It is important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

It is important that you eat a well-balanced diet with an adequate amount of calcium and vitamin D (found in milk or other dairy products). It is recommended that you receive calcium and vitamin D supplements while receiving this medicine.

It is important that you tell all of your health care providers that you are receiving ibandronate injection. If you are having dental procedures while using ibandronate injection, you may have an increased chance of getting a severe problem with your jaw.

Make sure you tell your doctor about any new medical problems, especially with your teeth or jaws. Tell your doctor if you have severe bone, joint, or muscle pain while using this medicine.

This medicine may increase your risk of developing fractures of the thigh bone. This may be more common if you use it for a long time. Check with your doctor right away if you have a dull or aching pain in the thighs, groin, or hips.

Boniva Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Back pain


• blurred vision


• difficulty with moving


• dizziness


• headache


• muscle pain or stiffness


• nervousness


• pain in the joints


• pounding in the ears


• slow or fast heartbeat

Less common

• Bladder pain


• bloody or cloudy urine


• body aches or pain


• chills


• cough


• cough producing mucus


• diarrhea


• difficult, burning, or painful urination


• difficulty with breathing


• ear congestion


• fever


• frequent urge to urinate


• general feeling of discomfort or illness


• loss of appetite


• loss of voice


• lower back or side pain


• muscle aches and pains


• muscle cramping


• nasal congestion


• nausea


• pain in the arms or legs


• pain, swelling, or redness in the joints


• runny nose


• shivering


• shortness of breath


• sneezing


• sore throat


• sweating


• swollen joints


• tightness in the chest


• trouble sleeping


• unusual tiredness or weakness


• vomiting


• wheezing

Incidence not known

• Blurred vision or other change in vision


• decreased vision


• eye pain


• eye redness


• eye tenderness


• increased tearing


• sensitivity of the eye to light


• severe eye pain


• tearing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Abdominal or stomach cramps


• bone pain


• confusion


• convulsions


• difficulty with breathing


• drowsiness


• irregular heartbeats


• muscle cramps in the hands, arms, feet, legs, or face


• muscle spasms (tetany) or twitching seizures


• numbness and tingling around the mouth, fingertips, or feet


• trembling


• tremor


• trouble breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach pain

Less common

• Acid or sour stomach


• belching


• burning feeling in the chest or stomach


• constipation


• diarrhea


• discouragement


• feeling sad or empty


• heartburn


• indigestion


• irritability


• lack of appetite


• loss of interest or pleasure


• rash


• red streaks on the skin


• sleeplessness


• stomach discomfort, upset, or pain


• stuffy nose


• swelling, tenderness, or pain at the injection site


• tenderness in the stomach area


• tiredness


• trouble concentrating


• unable to sleep


• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Boniva Intravenous side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Boniva Intravenous resources

• Boniva Intravenous Side Effects (in more detail)
• Boniva Intravenous Use in Pregnancy & Breastfeeding
• Drug Images
• Boniva Intravenous Drug Interactions
• Boniva Intravenous Support Group
• 12 Reviews for Boniva Intravenous - Add your own review/rating

Compare Boniva Intravenous with other medications

• Osteoporosis
• Prevention of Osteoporosis

Desenex Spray

Pronunciation: mi-KON-a-zole
Generic Name: Miconazole
Brand Name: Examples include Lotrimin AF and Micatin

Desenex Spray is used for:

Treating athlete's foot, jock itch, or ringworm and relieving the itching, scaling, burning, and discomfort due to those conditions. It may also be used for other conditions as determined by your doctor.

Desenex Spray is an antifungal. It works by weakening the fungal cell membrane, which kills the fungus.

Do NOT use Desenex Spray if:

• you are allergic to any ingredient in Desenex Spray

Contact your doctor or health care provider right away if any of these apply to you.

Before using Desenex Spray:

Some medical conditions may interact with Desenex Spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Desenex Spray. Because little, if any, of Desenex Spray is absorbed into the blood, the risk of it interacting with another medicine is low.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Desenex Spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Desenex Spray:

Use Desenex Spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Shake can well before using.


• Clean the affected area and dry it thoroughly.


• Hold can about 6 inches from the area to be treated and spray a thin layer of medicine over the affected area in the morning and at night or as directed by your doctor.


• Wash hands immediately after using Desenex Spray unless your hands are part of the treated area.


• For athlete's foot, pay special attention to the areas between the toes. Wear well-fitting, ventilated shoes, and change your shoes and socks at least once daily.


• To clear up your infection completely, continue using Desenex Spray for the full course of treatment even if you feel better in a few days.


• Supervise children in the use of this product.


• If you miss a dose of Desenex Spray, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Desenex Spray.

Important safety information:

• Desenex Spray is for external use only. Avoid contact with the eyes. If you get Desenex Spray in your eyes, rinse them immediately with a generous amount of cool water.


• Avoid inhaling the vapors of Desenex Spray.


• If Desenex Spray is swallowed, contact a doctor or poison control center immediately.


• Desenex Spray is flammable. Do not store or use near fire or other open flame. Do not use while smoking.


• Do not puncture or burn the container.


• Do not cover the treated area with a bandage or dressing unless directed otherwise by your doctor.


• If there is no improvement of athlete's foot or ringworm within 4 weeks or jock itch within 2 weeks, or if your condition persists, contact your health care provider.


• Desenex Spray is not effective on the scalp or nails.


• Do not use on CHILDREN younger than 2 years of age unless directed by a doctor.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Desenex Spray, discuss with your doctor the benefits and risks of using Desenex Spray during pregnancy. It is unknown if Desenex Spray is excreted in breast milk. If you are or will be breast-feeding while you are using Desenex Spray, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Desenex Spray:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); irritation.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Desenex Spray:

Store Desenex Spray at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Avoid temperatures above 120 degrees F (49 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Desenex Spray out of the reach of children and away from pets.

General information:

• If you have any questions about Desenex Spray, please talk with your doctor, pharmacist, or other health care provider.


• Desenex Spray is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Desenex Spray. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Desenex resources

• Desenex Use in Pregnancy & Breastfeeding
• Desenex Drug Interactions
• 0 Reviews for Desenex - Add your own review/rating

• Desenex Spray Concise Consumer Information (Cerner Multum)


• Absorbine Jr. Antifungal Topical Advanced Consumer (Micromedex) - Includes Dosage Information

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• Tinea Corporis
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Onxol

Generic Name: paclitaxel (PAK li TAK sel)

Brand Names: Onxol, Taxol

What is Onxol (paclitaxel)?

Paclitaxel is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Paclitaxel is used to treat breast cancer, lung cancer, and ovarian cancer. It is also used to treat AIDS-related Kaposi's sarcoma.

Paclitaxel may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Onxol (paclitaxel)?

Do not use this medication without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. You should not be given this medication if you are allergic to paclitaxel, or to other medications that contain an ingredient called Cremophor EL (polyoxyethylated castor oil). This includes cyclosporine (Gengraf, Neoral, Sandimmune) and teniposide (Vumon).

Before you receive paclitaxel, tell your doctor if you have liver disease, heart disease, or a severely weak immune system.

Paclitaxel can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

There are many other medicines that can interact with paclitaxel. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

What should I discuss with my healthcare provider before receiving Onxol (paclitaxel)?

You should not be given this medication if you are allergic to paclitaxel, or to other medications that contain an ingredient called Cremophor EL (polyoxyethylated castor oil). This includes cyclosporine (Gengraf, Neoral, Sandimmune) and teniposide (Vumon).

Before you receive paclitaxel, tell your doctor if you are allergic to any drugs, or if you have:

• liver disease;


• 
  

  heart disease; or

  
  


• 
  

  a severely weak immune system.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely receive paclitaxel.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not receive paclitaxel without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether paclitaxel passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How is paclitaxel given?

Paclitaxel is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion, and can take up to 24 hours to complete.

Paclitaxel is usually given every 3 weeks. Follow your doctor's instructions.

Before your injection, you may be given other medications to help prevent a serious allergic reaction to paclitaxel.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.

If any of this medication gets on your skin, wash the area with soap and warm water right away.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving paclitaxel.

Your heart rate may also be monitored through electrocardiograph or ECG (sometimes called an EKG). This machine measures electrical activity of the heart.

Paclitaxel can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

What happens if I miss a dose?

Contact your doctor if you miss an appointment for your paclitaxel injection.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

Overdose symptoms may include numbness or tingling, fever, chills, mouth sores, unusual bleeding or weakness, or any signs of infection.

What should I avoid while using Onxol (paclitaxel)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are being treated with paclitaxel.

Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Onxol (paclitaxel) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  slow heart rate;

  
  


• 
  

  seizure (black-out or convulsions);

  
  


• 
  

  pale skin, easy bruising or bleeding, unusual weakness;

  
  


• 
  

  fever, chills, body aches, flu symptoms;

  
  


• 
  

  white patches or sores inside your mouth or on your lips;

  
  


• 
  

  numbness, tingling, or burning pain in your hands or feet;

  
  


• 
  

  increased blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats); or

  
  


• 
  

  warmth or redness under your skin.

  
  

Less serious side effects may include:

• 
  

  pain, swelling, redness, or skin color changes where the medicine was injected;

  
  


• 
  

  joint or muscle pain;

  
  


• 
  

  mild nausea, vomiting, diarrhea; or

  
  


• 
  

  hair loss.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Onxol (paclitaxel)?

There are many other medicines that can interact with paclitaxel. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

More Onxol resources

• Onxol Side Effects (in more detail)
• Onxol Use in Pregnancy & Breastfeeding
• Onxol Drug Interactions
• Onxol Support Group
• 0 Reviews for Onxol - Add your own review/rating

• Onxol Prescribing Information (FDA)


• Onxol MedFacts Consumer Leaflet (Wolters Kluwer)


• Onxol Advanced Consumer (Micromedex) - Includes Dosage Information


• Paclitaxel Prescribing Information (FDA)


• Paclitaxel Professional Patient Advice (Wolters Kluwer)


• Paclitaxel Monograph (AHFS DI)


• Paclitaxel MedFacts Consumer Leaflet (Wolters Kluwer)


• Taxol Prescribing Information (FDA)


• Taxol Consumer Overview

Compare Onxol with other medications

• Breast Cancer
• Breast Cancer, Adjuvant
• Breast Cancer, Metastatic
• Kaposi's Sarcoma
• Non-Small Cell Lung Cancer
• Ovarian Cancer
• Wilms' Tumor

Where can I get more information?

• Your doctor or pharmacist can provide more information about paclitaxel.

See also: Onxol side effects (in more detail)

Orudis KT

Generic Name: ketoprofen (kee toe PROE fen)

Brand Names: Actron, Orudis KT

What is Orudis KT (ketoprofen)?

Ketoprofen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Ketoprofen works by reducing hormones that cause inflammation and pain in the body.

Ketoprofen is used to treat pain or inflammation caused by arthritis. It is also used to treat menstrual pain.

Ketoprofen may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Orudis KT (ketoprofen)?

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking ketoprofen. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

What should I discuss with my healthcare provider before taking Orudis KT (ketoprofen)?

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

You should not use this medication if you are allergic to ketoprofen, or to aspirin or other NSAIDs.

Before taking ketoprofen, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  a history of heart attack, stroke, or blood clot;

  
  


• 
  

  heart disease, congestive heart failure, high blood pressure;

  
  


• 
  

  a history of stomach ulcers or bleeding, bowel problems, diverticulosis;

  
  


• liver or kidney disease;


• 
  

  asthma;

  
  


• 
  

  polyps in your nose; or

  
  


• 
  

  if you smoke.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. It is not known whether ketoprofen is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether ketoprofen passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child without the advice of a doctor.

How should I take Orudis KT (ketoprofen)?

Take this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Ketoprofen should not be used to treat minor aches and pains.

If you take ketoprofen for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

Store ketoprofen at room temperature, away from moisture, heat, and light.

What happens if I miss a dose?

Since ketoprofen is sometimes taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, dizziness, drowsiness, black or bloody stools, coughing up blood, urinating less than usual or not at all, shallow breathing, fainting, seizure (convulsion), or coma.

What should I avoid while taking Orudis KT (ketoprofen)?

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain medicines similar to ketoprofen (such as aspirin, ibuprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, or naproxen. Do not drink alcohol while taking ketoprofen. Alcohol can increase the risk of stomach bleeding.

Orudis KT (ketoprofen) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking ketoprofen and seek medical attention or call your doctor at once if you have any of these serious side effects:

• 
  

  chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

  
  


• 
  

  black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  
  


• 
  

  confusion, tremors or shaking;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  
  


• 
  

  fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

  
  


• 
  

  bruising, severe tingling, numbness, pain, muscle weakness.

  
  

Less serious side effects may include:

• 
  

  upset stomach, mild heartburn or stomach pain, diarrhea, constipation; bloating, gas;

  
  


• 
  

  dizziness, headache, nervousness;

  
  


• 
  

  skin itching or rash;

  
  


• 
  

  dry mouth;

  
  


• 
  

  increased sweating, runny nose;

  
  


• 
  

  blurred vision; or

  
  


• 
  

  ringing in your ears.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Orudis KT (ketoprofen)?

Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with ketoprofen may cause you to bruise or bleed easily.

Before taking ketoprofen, tell your doctor if you are taking any of the following drugs:

• 
  

  cyclosporine (Gengraf, Neoral, Sandimmune);

  
  


• 
  

  lithium (Eskalith, Lithobid);

  
  


• 
  

  methotrexate (Rheumatrex, Trexall);

  
  


• 
  

  probenecid (Benemid);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin), or an anti-platelet medication such as clopidogrel (Plavix), dipyridamole (Persantine), ticlopidine (Ticlid), and others;

  
  


• 
  

  steroids (prednisone and others);

  
  


• 
  

  aspirin, or other NSAIDs such as diclofenac (Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Advil, Motrin), indomethacin (Indocin), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others.

  
  

This list is not complete and there may be other drugs that can interact with ketoprofen. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Orudis KT resources

• Orudis KT Side Effects (in more detail)
• Orudis KT Use in Pregnancy & Breastfeeding
• Orudis KT Drug Interactions
• Orudis KT Support Group
• 3 Reviews for Orudis KT - Add your own review/rating

• Orudis KT Advanced Consumer (Micromedex) - Includes Dosage Information


• Ketoprofen Prescribing Information (FDA)


• Ketoprofen Professional Patient Advice (Wolters Kluwer)


• Ketoprofen Monograph (AHFS DI)


• Ketoprofen MedFacts Consumer Leaflet (Wolters Kluwer)


• Orudis Prescribing Information (FDA)


• Oruvail Extended-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Orudis KT with other medications

• Back Pain
• Fever
• Frozen Shoulder
• Gout, Acute
• Osteoarthritis
• Pain
• Period Pain
• Rheumatoid Arthritis
• Sciatica

Where can I get more information?

• Your pharmacist can provide more information about ketoprofen.

See also: Orudis KT side effects (in more detail)

Betamethasone valerate Topical application

bay-ta-METH-a-sone VAL-er-ate

Commonly used brand name(s)

In the U.S.

• Betamethacot


• Beta-Val


• Luxiq


• Qualisone


• Valisone

In Canada

• Betacort Scalp Lotion


• Betnovate


• Betnovate-1/2


• Celestoderm-V


• Celestoderm-V/2


• Ectosone Mild-Lotion


• Ectosone Regular-Cream


• Ectosone Regular-Lotion


• Ectosone Scalp Lotion


• Metaderm Mild


• Metaderm Regular


• Novo-Betamet

Available Dosage Forms:

• Gel/Jelly


• Ointment


• Lotion


• Cream


• Foam

Therapeutic Class: Corticosteroid, Intermediate

Pharmacologic Class: Betamethasone

Uses For betamethasone valerate

Betamethasone topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. Betamethasone foam is used for scalp problems. betamethasone valerate is a corticosteroid (cortisone-like medicine or steroid).

betamethasone valerate is available only with your doctor's prescription.

Before Using betamethasone valerate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For betamethasone valerate, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to betamethasone valerate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of betamethasone topical in the pediatric population. However, because of betamethasone valerate's toxicity, it should be used with caution. Children may absorb large amounts through the skin, which can cause serious side effects. If your child is using betamethasone valerate, follow your doctor's instructions very carefully. For the foam form, safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of betamethasone topical in geriatric patients.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of betamethasone valerate. Make sure you tell your doctor if you have any other medical problems, especially:

• Cushing's syndrome (adrenal gland disorder) or


• Diabetes or


• Hyperglycemia (high blood sugar) or


• Intracranial hypertension (increased pressure in the head)—Use with caution. May make these conditions worse.

• Infection of the skin at or near the place of application or


• Large sores, broken skin, or severe skin injury at the place of application—The chance of side effects may be increased.

Proper Use of betamethasone valerate

It is very important that you use betamethasone valerate only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.

betamethasone valerate is for use on the skin only. Do not get it in your eyes. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.

betamethasone valerate should only be used for skin conditions that your doctor is treating. Check with your doctor before using it for other conditions, especially if you think that an infection may be present. betamethasone valerate should not be used to treat certain kinds of skin infections or conditions, such as severe burns.

To use cream, lotion, or ointment:

• Wash your hands with soap and water before and after using betamethasone valerate.


• Apply a thin layer of betamethasone valerate to the affected area of the skin. Rub it in gently.


• With the lotion, protect the skin from water, clothing, or anything that causes rubbing until the medicine has dried. Also, shake the lotion well before using it.


• Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.


• If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.


• If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

To use the foam:

• betamethasone valerate comes with a patient information insert. Read and follow the instructions carefully.


• Wash your hands with soap and water before and after using betamethasone valerate.


• Turn the can upside down and place a small amount of medicine in a saucer or any cool, clean surface. Do not put the foam directly in your hands. This will melt the foam immediately upon contact with warm skin.


• Move the hair away and put a small amount of the foam on the affected areas of the scalp. Massage it in gently until the medicine has dried.


• Do not wash or rinse the treated areas immediately after applying the medicine.


• Do not use betamethasone valerate near heat, open flame, or while smoking.

Dosing

The dose of betamethasone valerate will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of betamethasone valerate. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For redness, itching, and swelling of the skin:
  
  • For topical dosage forms (cream and ointment):
    
    • Adults—Apply to the affected area of the skin one to three times per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For topical dosage form (lotion):
    
    • Adults—Apply a few drops to the affected area of the skin two times per day (morning and evening).
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  


• For scalp problems:
  
  • For topical dosage form (foam):
    
    • Adults—Apply to the affected area of the scalp two times per day (once in the morning and once at night).
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of betamethasone valerate, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the can of the foam at room temperature, away from heat and direct light. Do not freeze. Do not keep betamethasone valerate inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Precautions While Using betamethasone valerate

It is very important that your doctor check the progress of you or your child at regular visits for any unwanted effects that may be caused by betamethasone valerate.

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Using too much of betamethasone valerate or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor if you or your child have more than one of these symptoms while you are using betamethasone valerate: blurred vision; dizziness or fainting; a fast, irregular, or pounding heartbeat; increased thirst or urination; irritability; or unusual tiredness or weakness.

Stop using betamethasone valerate and check with your doctor right away if you or your child have a skin rash, burning, stinging, swelling, or irritation on the skin.

Do not use cosmetics or other skin care products on the treated areas.

betamethasone valerate Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Burning, itching, or stinging at the application site

Less common

• Hair loss


• thinning of the hair

Incidence not known

• Blistering, burning, crusting, dryness, or flaking of the skin


• irritation


• itching, scaling, severe redness, soreness, or swelling of the skin


• redness and scaling around the mouth


• thinning of the skin with easy bruising, especially when used on where the skin folds together (e.g. between the fingers)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Acne or pimples


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

Incidence not known

• Burning and itching of the skin with pinhead-sized red blisters


• burning, itching, and pain in hairy areas, or pus at the root of the hair


• increased hair growth on the forehead, back, arms, and legs


• lightening of normal skin color


• lightening of treated areas of dark skin


• reddish purple lines on the arms, face, legs, trunk, or groin


• softening of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More betamethasone valerate Topical application resources

• Betamethasone valerate Topical application Use in Pregnancy & Breastfeeding
• Betamethasone valerate Topical application Drug Interactions
• Betamethasone valerate Topical application Support Group
• 13 Reviews for Betamethasone valerate Topical application - Add your own review/rating

Compare betamethasone valerate Topical application with other medications

• Atopic Dermatitis
• Dermatitis
• Dermatological Disorders
• Lichen Planus
• Lichen Sclerosus

Bismuth Original Formula

Generic Name: bismuth subsalicylate (Oral route)

BIZ-muth sub-sa-LIS-i-late

Commonly used brand name(s)

In the U.S.

• Bismatrol


• Diotame


• Kaopectate


• Kapectolin


• Kola-Pectin


• Pepto Bismol

In Canada

• Bismuth Extra Strength


• Bismuth Original Formula


• Pepto-Bismol


• Stomach Relief - Regular Formula

Available Dosage Forms:

• Suspension


• Tablet, Chewable


• Tablet

Therapeutic Class: Antacid, Bismuth Containing

Chemical Class: Salicylate, Non-Aspirin

Uses For Bismuth Original Formula

Bismuth subsalicylate is used to treat diarrhea in adults and teenagers. It is also used to relieve the symptoms of an upset stomach, such as heartburn, indigestion, and nausea in adults and teenagers.

This medicine is available without a prescription.

Before Using Bismuth Original Formula

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine should not be used in children younger than 12 years of age. The fluid loss caused by diarrhea may result in a severe condition. In older children with diarrhea, medicine for diarrhea may be used, but it is also very important that a sufficient amount of liquids be given to replace the fluid lost by the body. If you have any questions about this, check with your health care professional.

Also, children are usually more sensitive to the effects of salicylates, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating.

The bismuth in this medicine may cause severe constipation in children.

In addition, do not use this medicine to treat nausea or vomiting in children or teenagers who have or are recovering from the flu or chickenpox. If nausea or vomiting is present, check with the child's doctor immediately because this could be an early sign of Reye's syndrome.

Geriatric

The fluid loss caused by diarrhea may result in a severe condition. For this reason, elderly persons with diarrhea should not take this medicine without first checking with their doctor. It is also very important that a sufficient amount of liquids be taken to replace the fluid lost by the body. If you have any questions about this, check with your health care professional.

Also, the elderly may be more sensitive to the effects of salicylates. This may increase the chance of side effects during treatment. In addition, the bismuth in this medicine may cause severe constipation in the elderly.

Breast Feeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Methotrexate

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Doxycycline


• Probenecid


• Sulfinpyrazone


• Tamarind

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Dysentery—This condition may get worse; a different kind of treatment may be needed

• Gout—The salicylate in this medicine may worsen the gout and make the medicines taken for gout less effective

• Hemophilia or other bleeding problems—The salicylate in this medicine may increase the chance of bleeding

• Kidney disease—There is a greater chance of side effects because the body may be unable to get rid of the bismuth subsalicylate

• Stomach ulcer—Use of this medicine may make the ulcer worse

Proper Use of bismuth subsalicylate

This section provides information on the proper use of a number of products that contain bismuth subsalicylate. It may not be specific to Bismuth Original Formula. Please read with care.

Make certain your health care professional knows if you are on any special diet, such as a low-sodium or low-sugar diet.

For safe and effective use of this medicine:

• Follow your doctor's instructions if this medicine was prescribed.


• Follow the manufacturer's package directions if you are treating yourself.

For patients using this medicine to treat diarrhea:

• It is very important that the fluid lost by the body be replaced and that a proper diet be followed. For the first 24 hours you should drink plenty of clear liquids, such as ginger ale, decaffeinated cola, decaffeinated tea, broth, and gelatin. During the next 24 hours you may eat bland foods, such as cooked cereals, bread, crackers, and applesauce. Fruits, vegetables, fried or spicy foods, bran, candy, and caffeine and alcoholic beverages may make the diarrhea worse.


• If too much fluid has been lost by the body due to the diarrhea a serious condition may develop. Check with your doctor as soon as possible if any of the following signs of too much fluid loss occur:
  
  • Decreased urination
  
  
  • Dizziness and lightheadedness
  
  
  • Dryness of mouth
  
  
  • Increased thirst
  
  
  • Wrinkled skin
  
  

If you are taking the oral suspension: Use the dose cup that is included to measure out the right amount of medicine. If you are unsure, contact your doctor or pharmacist.

If you are taking the oral tablets: Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

If you are taking the chewable tablets: Chew up the tablet or allow it to completely disintegrate in your mouth before swallowing it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (suspension):
  
  • For diarrhea or upset stomach:
    
    • Adults and teenagers—The usual dose is 2 tablespoonfuls every half-hour to one hour if needed. You should not take more than 16 tablespoonfuls of the regular-strength suspension or 8 tablespoonfuls of the concentrate in twenty-four hours.
    
    
    • Children—Should not be used in children younger than 12 years of age.
    
    
  
  


• For oral dosage forms (tablets or chewable tablets):
  
  • For diarrhea or upset stomach:
    
    • Adults and teenagers—The usual dose is 2 tablets every half-hour to one hour. You should not take more than 16 tablets in twenty-four hours.
    
    
    • Children—Should not be used in children younger than 12 years of age.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Bismuth Original Formula

Check the labels of all over-the-counter (OTC), nonprescription, and prescription medicines you now take. If any contain aspirin or other salicylates, be especially careful. Using other salicylate-containing products while taking this medicine may lead to overdose. If you have any questions about this, check with your health care professional.

For diabetic patients:

• False urine sugar test results may occur if you are regularly taking large amounts of bismuth subsalicylate or other salicylates.


• Smaller doses or occasional use of bismuth subsalicylate usually will not affect urine sugar tests. However, check with your health care professional (especially if your diabetes is not well-controlled) if:
  
  • you are not sure how much salicylate you are taking every day.
  
  
  • you notice any change in your urine sugar test results.
  
  
  • you have any other questions about this possible problem.
  
  

If you think that you or anyone else may have taken an overdose, get emergency help at once. Taking an overdose of this medicine may cause unconsciousness or death. Signs of overdose include convulsions (seizures), hearing loss, confusion, ringing or buzzing in the ears, severe drowsiness or tiredness, severe excitement or nervousness, and fast or deep breathing.

If you are taking this medicine for diarrhea, check with your doctor:

• if your symptoms do not improve within 2 days or if they become worse.


• if you also have a high fever.

Bismuth Original Formula Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

In some patients bismuth subsalicylate may cause dark tongue and/or grayish black stools. This is only temporary and will go away when you stop taking this medicine.

• Anxiety


• any loss of hearing


• confusion


• constipation (severe)


• diarrhea (severe or continuing)


• difficulty in speaking or slurred speech


• dizziness or lightheadedness


• drowsiness (severe)


• fast or deep breathing


• headache (severe or continuing)


• increased sweating


• increased thirst


• mental depression


• muscle spasms (especially of face, neck, and back)


• muscle weakness


• nausea or vomiting (severe or continuing)


• ringing or buzzing in ears (continuing)


• stomach pain (severe or continuing)


• trembling


• uncontrollable flapping movements of the hands (especially in elderly patients) or other uncontrolled body movements


• vision problems

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Bismuth Original Formula side effects (in more detail)

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More Bismuth Original Formula resources

• Bismuth Original Formula Side Effects (in more detail)
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• Drug Images
• Bismuth Original Formula Drug Interactions
• Bismuth Original Formula Support Group
• 4 Reviews for Bismuth Original Formula - Add your own review/rating

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